一、基本情况
孔洁倩，药学博士，校聘副教授。主要从事合成生物学和新药发现相关研究工作。目前主持湖南省教育厅课题和必威betway西汉姆博士人才引进科研启动基金项目。在J Nat Prod、Biomed Pharmacother、Org Lett、Appl Microbiol Biotechnol、Mol Pharm等国际权威杂志发表科研论文8篇。
Email：jqkong@usc.edu.com
二、研究领域
1. 活性微生物天然产物的发现及其生物活性研究
2. 抗肿瘤药物的新型纳米递送系统开发
三、工作及学习经历
2025/01-至今，必威betway西汉姆，bw必威西汉姆联官网
2020/09-2024/06，中南大学，药学专业，博士
2019/07-2020/05，正大天晴药业集团股份有限公司，临床监查员
2016/09-2019/06，中南大学，药学专业，硕士
2012/09-2016/06，广西师范大学，化学专业，本科
四、社会兼职
无
五、教学工作
目前承担课程：《药用有机化学》。
六、承担课题
1．湖南省教育厅，一般项目，CX20230288，基于化疗和铁死亡协同肿瘤治疗策略构建博来霉素铁基MOF纳米递送系统，2023-01至2024-03。
2．必威betway西汉姆博士人才引进科研启动基金项目，5525QD021，铁多酚纳米载体构建及其用于博来霉素的增效减毒研究，2025-01至2028-01。
七、代表性科研论文
[1] Kong J, Huang C, Xiong Y, Li B, Kong W, Liu W, Tan Z, Peng D, Duan Y* and Zhu X*. Discovery and biosynthetic studies of a highly reduced cinnamoyl lipid tripmycin A in endophytic Streptomyces sp. J Nat Prod, 2023, 86: 1870-1877.
[2] Kong J, Xiong Y, Duan Y* and Zhu X*. Deoxidized gulose moiety attenuates the pulmonary toxicity of 6'-deoxy-bleomycin Z without effect on its antitumor activity. Biomed Pharmacother, 2021, 136: 111222.
[3] Kong J, Yi L, Xiong Y, Huang Y, Yang D, Yan X, Shen B, Duan Y* and Zhu X*. The discovery and development of microbial bleomycin analogues. Appl Microbiol Biotechnol, 2018, 102: 6791-6798.
[4] Yi L, Yi S, Wang Y, Kong J, Xiong Y, Zhou Y, Duan Y* and Zhu X*. Late-stage tailoring steps in the biosynthesis of β-Rubromycin involve successive terminal oxidations, a selective hydroxyl reduction, and distinctive o-methylations. Org Lett, 2025, 27:103-108.
[5] Xiong Y, Kong J, Yi S, Tan Q, Bai E, Ren N, Huang Y, Duan Y* and Zhu X*. Lipopeptide surfactin ameliorates the cell uptake of platensimycin and enhances its therapeutic effect on treatment of MRSA skin infection. J Antimicrob Chemother, 2022, 77: 2840-2849.
[6] Yi L, Kong J, Xiong Y, Yi S, Gan T, Huang C, Duan Y* and Zhu X*. Genome mining of Streptomyces sp. CB00271 as a natural high-producer of β-rubromycin and the resulting discovery of β-rubromycin acid. Biotechnol Bioeng, 2021, 118: 2243-2254.
[7] Xiong Y, Kong J, Yi S, Feng X, Duan Y* and Zhu X*. Surfactin ameliorated the internalization and inhibitory performances of bleomycin family compounds in tumor cells. Mol Pharm, 2020, 17: 2125-2134.
[8] Zhu X*, Kong J, Yang H, Huang R, Huang Y, Yang D, Shen B, Duan Y*. Strain improvement by combined UV mutagenesis and ribosome engineering and subsequent fermentation optimization for enhanced 6'-deoxy-bleomycin Z production. Appl Microbiol Biotechnol, 2018, 102: 1651-1661.
上一条：李 坚